Amyotrophic Lateral Sclerosis (ALS) - Revision history

Kirabug at 00:01, 11 September 2021

2021-09-11T00:01:26Z

← Older revision		Revision as of 17:01, 10 September 2021
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	ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.~~wikipedia~~.~~org~~/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.		This information has been moved to [https://accessibility.perpendicularangel.com/what-is-accessibility/types-of-disabilities/physical-disabilities/amyotrophic-lateral-sclerosis-als/ Amyotrophic Lateral Sclerosis (ALS)] at [[Perpendicular Angel]].

	~~The [[Centers for Disease Control (CDC)]] estimated in 2016 that 14,000~~-~~15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders~~/~~Patient~~-~~Caregiver~~-~~Education~~/~~Fact~~-~~Sheets~~/~~Amyotrophic~~-~~Lateral~~-~~Sclerosis~~-~~ALS-Fact-Sheet~~ Amyotrophic Lateral Sclerosis (ALS) ~~Fact Sheet~~], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.

	~~==What People with ALS have to say==~~

	[[~~Marie-France Bru~~]] ~~demonstrates the use of a cheek switch and custom virtual keyboards to manipulate her computer back in 2005~~.
	~~<YouTube>https://www.youtube.com/watch?v=ENkjkIypXq4</YouTube>~~

	[[Category:Physical Disabilities]]		[[Category:Physical Disabilities]]

Kirabug at 03:44, 21 July 2020

2020-07-21T03:44:09Z

← Older revision		Revision as of 20:44, 20 July 2020
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	The [[Centers for Disease Control (CDC)]] estimated in 2016 that 14,000-15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet Amyotrophic Lateral Sclerosis (ALS) Fact Sheet], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.		The [[Centers for Disease Control (CDC)]] estimated in 2016 that 14,000-15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet Amyotrophic Lateral Sclerosis (ALS) Fact Sheet], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.

			==What People with ALS have to say==

			[[Marie-France Bru]] demonstrates the use of a cheek switch and custom virtual keyboards to manipulate her computer back in 2005.
			<YouTube>https://www.youtube.com/watch?v=ENkjkIypXq4</YouTube>

	[[Category:Physical Disabilities]]		[[Category:Physical Disabilities]]

Kirabug at 22:44, 20 July 2020

2020-07-20T22:44:09Z

← Older revision		Revision as of 15:44, 20 July 2020
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	ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.wikipedia.org/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.		ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.wikipedia.org/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.

	The [[Centers for Disease Control]] estimated in 2016 that 14,000-15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet Amyotrophic Lateral Sclerosis (ALS) Fact Sheet], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.		The [[Centers for Disease Control (CDC)]] estimated in 2016 that 14,000-15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet Amyotrophic Lateral Sclerosis (ALS) Fact Sheet], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.

	[[Category:Physical Disabilities]]		[[Category:Physical Disabilities]]

Kirabug at 22:43, 20 July 2020

2020-07-20T22:43:48Z

← Older revision		Revision as of 15:43, 20 July 2020
Line 1:		Line 1:
	ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.wikipedia.org/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.		ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.wikipedia.org/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.

	The [[Centers for Disease Control ~~and Prevention~~]] ~~estimate for In~~ 2016 ~~the Centers for Disease Control and Prevention estimated~~ that ~~between~~ 14,000 - 15,000 Americans have ALS. ALS ~~is a common neuromuscular disease worldwide~~. ~~It affects people~~ of ~~all races~~ and ~~ethnic backgrounds~~.		The [[Centers for Disease Control]] estimated in 2016 that 14,000-15,000 Americans have ALS. Generally, the disease occurs between ages 55 and 75. According to the [https://www.ninds.nih.gov/disorders/Patient-Caregiver-Education/Fact-Sheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet Amyotrophic Lateral Sclerosis (ALS) Fact Sheet], some studies suggest military veterans are more likely to develop ALS. Ninety percent or more of ALS cases are considered sporadic, with no clear risk factors or family history. About 5-10% of cases are familial (genetic) ALS, and specific gene mutations have been identified as the cause.

	~~There are several potential risk factors for ALS including~~:		[[Category:Physical Disabilities]]

	~~Age. Although the disease can strike at any age, symptoms most commonly develop between the ages of 55 and 75.~~
	~~Gender. Men are slightly more likely than women to develop ALS. However, as we age the difference between men and women disappears.~~
	~~Race and ethnicity. Most likely to develop the disease are Caucasians and non-Hispanics.~~
	Some studies suggest that military veterans are about 1.5 to 2 times more likely to develop ALS. Although the reason for this is unclear, possible risk factors for veterans include exposure to lead, pesticides, and other environmental toxins. ALS is recognized as a service-connected disease by the U.S. Department of Veterans Affairs.

	~~Sporadic ALS~~
	The majority of ALS cases (90 percent or more) are considered sporadic. This means the disease seems to occur at random with no clearly associated risk factors and no family history of the disease. Although family members of people with sporadic ALS are at an increased risk for the disease, the overall risk is very low and most will not develop ALS.

	~~Familial (Genetic) ALS~~
	About 5 to 10 percent of all ALS cases are familial, which means that an individual inherits the disease from his or her parents. The familial form of ALS usually only requires one parent to carry the gene responsible for the disease. Mutations in more than a dozen genes have been found to cause familial ALS. About 25 to 40 percent of all familial cases (and a small percentage of sporadic cases) are caused by a defect in a gene known as “chromosome 9 open reading frame 72,” or C9ORF72. Interestingly, the same mutation can be associated with atrophy of frontal-temporal lobes of the brain causing frontal-temporal lobe dementia. Some individuals carrying this mutation may show signs of both motor neuron and dementia symptoms (ALS-FTD). Another 12 to 20 percent of familial cases result from mutations in the gene that provides instructions for the production of the enzyme copper-zinc superoxide dismutase 1 (SOD1).

Kirabug: Created page with "ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervo..."

2020-07-20T22:38:35Z

Created page with "ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervo..."

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ALS is the group name for certain degenerative neuromuscular diseases. Degenerative means it progressively gets worse over time. Neuromuscular means it involves both the nervous system and the muscular system. In the case of ALS, [https://en.wikipedia.org/wiki/Motor_neuron motor neurons] gradually deteriorate and die. As a result, muscles gradually weaken, twitch, and atrophy. Eventually the brain loses the ability to initiate and control voluntary movements.

The [[Centers for Disease Control and Prevention]] estimate for In 2016 the Centers for Disease Control and Prevention estimated that between 14,000 - 15,000 Americans have ALS. ALS is a common neuromuscular disease worldwide. It affects people of all races and ethnic backgrounds.

There are several potential risk factors for ALS including:

Age. Although the disease can strike at any age, symptoms most commonly develop between the ages of 55 and 75.
Gender. Men are slightly more likely than women to develop ALS. However, as we age the difference between men and women disappears.
Race and ethnicity. Most likely to develop the disease are Caucasians and non-Hispanics.
Some studies suggest that military veterans are about 1.5 to 2 times more likely to develop ALS. Although the reason for this is unclear, possible risk factors for veterans include exposure to lead, pesticides, and other environmental toxins. ALS is recognized as a service-connected disease by the U.S. Department of Veterans Affairs.

Sporadic ALS
The majority of ALS cases (90 percent or more) are considered sporadic. This means the disease seems to occur at random with no clearly associated risk factors and no family history of the disease. Although family members of people with sporadic ALS are at an increased risk for the disease, the overall risk is very low and most will not develop ALS.

Familial (Genetic) ALS
About 5 to 10 percent of all ALS cases are familial, which means that an individual inherits the disease from his or her parents. The familial form of ALS usually only requires one parent to carry the gene responsible for the disease. Mutations in more than a dozen genes have been found to cause familial ALS. About 25 to 40 percent of all familial cases (and a small percentage of sporadic cases) are caused by a defect in a gene known as “chromosome 9 open reading frame 72,” or C9ORF72. Interestingly, the same mutation can be associated with atrophy of frontal-temporal lobes of the brain causing frontal-temporal lobe dementia. Some individuals carrying this mutation may show signs of both motor neuron and dementia symptoms (ALS-FTD). Another 12 to 20 percent of familial cases result from mutations in the gene that provides instructions for the production of the enzyme copper-zinc superoxide dismutase 1 (SOD1).